A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jawed, Rihan
- Effect of Ultraviolet Radiation on various Bacterial Species
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 1 - 4Abstract
The study of microorganism is called microbiology, which includes bacteria, viruses, fungi and Protozoa. Microbes play a major role in this field. Microbes are also used for life-saving drugs etc. The effect of ultraviolet rays on the bacteria’s are mostly lethal to them, UV is a minor fraction of the solar spectrum reaching the ground surfaces, the UV light radiation will reduce the microbes in the surroundings as well as in the labs. The aim of this study was to evaluate the effect of the ultraviolet rays on pathogenic bacteria’s. Three organisms were selected for the study. Staphylococcus aureus and Streptococcus faecalis. 30 watts UV tube was used to evaluate the antibacterial activity of the UV radiation. The exposure time was determined as 5, 10 and 15 mins at a close distance of 10cm. 20 microliter of suspension was taken and mixed in 2 ml of sterile normal saline and exposed for respective duration. Sub culture was done on suitable media after the exposure. Time exposed plates were incubated at 37 degree Celsius overnight and checked for the total CFU and data were tabulated. The Ultra violet radiation of pathogenic bacteria resulted in a significant total colony forming unit. Ultraviolet rays were lethal to the bacteria’s. There are many airborne bacteria’s surrounded by environment ultraviolet rays exposure will cause an apparent decrease in the pathogenic bacteria’s.
Keywords
Bacteria, Effect, Eco friendly, Pathogenic and Ultraviolet, Innovative technology, Innovative techniqueReferences
- Gascon J, oubina A, Perez-Lezaun A, Urmeneta J. Sensitivity of selected bacterial species to UV radiation. Current Microbiology. 1995; 30(3):177-82.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co- Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021;14(3):1535-41.
- Jahani R, Mojab F, Mahboubi A, Nasiri A, Tahamtani A, Faizi M. An In-Vivo Study on Anticonvulsant, Anxiolytic, and Sedative- Hypnotic Effects of the Polyphenol-Rich Thymus Kotschyanus Extract; Evidence for the Involvement of GABAA Receptors. Iranian Journal of Pharmaceutical Research. 2019;18(3):1456.
- Khatua S, Paul S, Acharya K. Mushroom as the potential source of new generation of antioxidant: a review. Research Journal of Pharmacy and Technology. 2013; 6(5):496-505.
- Karthikeyan D, Bhowmick M, Pandey VP, Sengottuvelu S, Sonkar S, Gupta N, Mohod V, Shivakumar T. Design and evaluation of ofloxacin extended release ocular inserts for once a day therapy. Research Journal of Pharmacy and Technology. 2008;1(4):460-8.
- John SL, Williams GP, Brijithlal ND, Namitha LH, Krishnakumar S. Effect of UV-β radiation on the Growth, Pigment production and Macromolecular contents in Marine microalgae. Research Journal of Pharmacy and Technology. 2019;12(12): 5888-92.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021;55(1): 86-94.
- Chakraborty P, Kumar S, Dutta D, Gupta V. Role of antioxidants in common health diseases. Research Journal of Pharmacy and Technology. 2009; 2(2): 238-44.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020;13(1): 4745-52.
- Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A Review. Research Journal of Pharmacy and Technology. 2008;1(4):328-40.
- Saravanan R, Dhachinamoorthi D, Senthil Kumar K, Vinodkumar S, Nikhileshbabu M, Neeraj J. Effects of UV-B Enhanced Solar Radiation on Trigonella foenum-graecum. Research J. Pharm. and Tech. 2012;5(3):328-32.
- Khelker T, Haque N, Agrawal A. Ultraviolet Protection potential of Curcuma longa L. and Citrus sinensis (L.) Osbeck. Research Journal of Pharmacy and Technology. 2017; 10(12):4282-4.
- Kadivar H, Stapleton AE. Ultraviolet radiation alters maize phyllosphere bacterial diversity. Microbial Ecology. 2003; 1:353- 61.
- Yang Y, Itahashi S, Yokobori SI, Yamagishi A. UV-resistant bacteria isolated from upper troposphere and lower stratosphere. Biological Sciences in Space. 2008; 22(1):18-25.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
- Hader DP, Helbling EW, Williamson CE, Worrest RC. Effects of UV radiation on aquatic ecosystems and interactions with climate change. Photochemical & Photobiological Sciences. 2011; 10(2): 242-60. 18. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
- Pausz C, Herndl GJ. Role of nitrogen versus phosphorus availability on the effect of UV radiation on bacterioplankton and their recovery from previous UV stress. Aquatic Microbial Ecology. 2002; 29(1): 89-95.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020; 13(3): 4942-51.
- An Updated Review on Preparation and Characterization of Solid Lipid Nanoparticles
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Angola, TR
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 313-319Abstract
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage. Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. Appropriate analytical techniques for the characterization of SLN like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers are also discussed.Keywords
SLM, Production Technique, Lipid Based Carrier, Pharmaceutical ApplicationReferences
- Sachin J, Gupta NV. Solid lipid nanoparticles–preparation, applications, characterization, uses in various cancer therapies: a review. Research Journal of Pharmacy and Technology. 2013;6(8):825-37.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya V, Manekar S. Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo Co-Agglomeration technique. Evaluation. 2021 Mar 1;1(1):1.
- Mulla JA, Suresh S, Khazi IA. Formulation, characterization and in vitro evaluation of methotrexate solid lipid nanoparticles. Research Journal of Pharmacy and Technology. 2009;2(4):685-9.
- Nachammai K, Nair KG, RamaiyanVelmurugan SK. Sustained–Release study on Mefenamic acid and Mosapride loaded solid lipid Nanoparticles: In vitro Characterization. Research Journal of Pharmacy and Technology. 2020 Nov 13;13(11):5391-5.
- Gholse YN, Yeole MP. Microencapsulation for the therapeutic delivery of Proteins and other drugs: Update and future challenges. Research Journal of Pharmacy and Technology. 2013;6(5):465-76.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- Patel D, Prajapati ST, Patel CN, Patel J, Savan V. A Review on Insoluble Drug Delivery Technology. Research Journal of Pharmacy and Technology. 2010;3(2):333-8.
- Dhiman S, Singh TG, Anand S, Yadav P. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021 May 26;14(5):2548-56.
- Veni DK, Gupta NV. Quality by Design approach in the development of Solid Lipid Nanoparticles of Linagliptin. Research Journal of Pharmacy and Technology. 2019;12(9):4454-62.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Hou D, Xie C, Huang K, Zhu C. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials. 2003 May 1;24(10):1781-5.
- Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Advanced drug delivery reviews. 2012 Dec 1;64:83-101.
- Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. European journal of pharmaceutics and biopharmaceutics. 2000 Jul 3;50(1):161-77.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Üner M, Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. International journal of nanomedicine. 2007 Sep;2(3):289.
- Morel S, Ugazio E, Cavalli R, Gasco MR. Thymopentin in solid lipid nanoparticles. International journal of pharmaceutics. 1996 Apr 30;132(1-2):259-61.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Advanced pharmaceutical bulletin. 2015 Sep;5(3):305.
- Tiyaboonchai W, Tungpradit W, Plianbangchang P. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 2007 Jun 7;337(1-2):299-306.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of TeneligliptinHydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- zurMühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. European journal of pharmaceutics and biopharmaceutics. 1998 Mar 1;45(2):149-55.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 1 (2022), Pagination: 23-28Abstract
Current research is focused on formulation and evaluation of natural gum based fast dissolving tablet of Cefixime trihydrate by applying 32 factorial designs for the improvement of the drug absorption. Direct compression method was used. Two factors as independent variable (x1) Fenugreek mucilage(x2) sodium saccharin glycolate were taken with three level (+1, 0,-1). The level two factors were selected on basis of preliminary experiments conducted and their effect on dependent variable (disintegration time) was estimated. Formulated tablets were evaluated for parameters in which the values were found to be in the range of hardness 2.1-2.6 kg/cm2 , thickness 2.227-2.296 mm, weight variance 182-196 mg, wetting time 58-68 seconds, waterabsorption ratio 0.1628-0.2439, disintegration time 56 sec – 9 min, and friability 0.53-0.68 %. The software design expert (11.0) was used for getting experimental design, modeling the response surface and calculating the static evaluation. The tablet parameters tests of formulation (F1 to F10) were observed within prescribe limit. Disintegration time observed 56 seconds, % cumulative drug release 88.79 % to 98.90 %. Batch F6 was observed as promising batch.Keywords
Cefixime trihydrate, Fenugreek mucilage powder, Fast Dissolving tablets, Pharmaceutical excipients.References
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Rajesh A, Manmeet K, Sangeeta A. Formulation and evaluation of fast dissolving tablet of Pioglitazone. Research Journal of Pharmacy and Technology. 2012;5(6):817-21.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Patel P, Kumar PA, Shah H, Patel N, Kheni P, Rao BS, Kulkarni SV, Babitha S. Formulation and Evaluation of Fast Dissolving Tablet of Telmisartan. Research Journal of Pharmacy and Technology. 2011;4(6):955-61.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Madoria N, Maheshwari Y. Formulation, Optimization and Characterization of Fast Dissolving Tablet of Celecoxib. Research Journal of Pharmacy and Technology. 2012;5(8):1085-8.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Sharma S, Bharadwaj S, Gupta GD. Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants. Research Journal of Pharmacy and Technology. 2008;1(3):218-24.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Cefixime trihydrate for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Kumar K, Chopra H, Sharma GK. Formulation and evaluation of fast dissolving tablet of montelukast by using co-processed excipients. Research Journal of Pharmacy and Technology. 2019;12(11):5543-8.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Mahesh PG, Raman SG. Formulation and Evaluation of Fast Dissolving Tablet of Prasugrel. Research Journal of Pharmacy and Technology. 2021 Aug 1;14(8):4077-9.
- Giri TK, Sa B. Formulation of rapidly disintegrating fast dissolving diazepam tablets using solid dispersions through a statistical approach. Research Journal of Pharmacy and Technology. 2010;3(4):1246-51.
- Deshmukh SS, Quazi A, Saraf A. Formulation and Evaluation of Fast Dissolving Tablets of Chlorpromazine Hydrochloride Using Novel Co-processed Superdisintegrants. Research Journal of Pharmacy and Technology. 2012;5(9):1235-40.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal Of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Ratnaparkhi MP, Karnawat GR, Andhale RS. Natural polymers in fast dissolving tablets. Research Journal of Pharmacy and Technology. 2021 May 1;14(5):2859-66.
- Dave V, Yadav RB, Ahuja R, Yadav S. Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques. Bulletin of Faculty of Pharmacy, Cairo University. 2017 Jun 1;55(1):31-9.
- Lal M, Priddy S, Bourgeois L, Walker R, Pebley W, Brown J, Desai J, Darsley MJ, Kristensen D, Chen D. Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate. Vaccine. 2013 Oct 1;31(42):4759-64.
- Antonijoan R, García-Gea C, Puntes M, Pérez J, Esbrí R, Serra C, Fortea J, Barbanoj MJ. Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, doubledummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults. Clinical therapeutics. 2007 May 1;29(5):814-22.
- Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L. Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics. 2008 Nov 1;70(3):895-900.
- Effect of Ultraviolet Radiation on Various Bacterial Species
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 1 (2022), Pagination: 39-42Abstract
The study of microorganism is called microbiology, which includes bacteria, viruses, fungi and Protozoa. Microbes play a major role in this field. Microbes are also used for life-saving drugs etc. The effect of ultraviolet rays on the bacteria’s are mostly lethal to them, UV is a minor fraction of the solar spectrum reaching the ground surfaces, the UV light radiation will reduce the microbes in the surroundings as well as in the labs. The aim of this study was to evaluate the effect of the ultraviolet rays on pathogenic bacteria’s. Three organisms were selected for the study. Staphylococcus aureus and Streptococcus faecalis. 30 watts UV tube was used to evaluate the antibacterial activity of the UV radiation. The exposure time was determined as 5, 10 and 15 mins at a close distance of 10cm. 20 microliter of suspension was taken and mixed in 2 ml of sterile normal saline and exposed for respective duration. Sub culture was done on suitable media after the exposure. Time exposed plates were incubated at 37 degree Celsius overnight and checked for the total CFU and data were tabulated. The Ultra violet radiation of pathogenic bacteria resulted in a significant total colony forming unit. Ultraviolet rays were lethal to the bacteria’s. There are many airborne bacteria’s surrounded by environment ultraviolet rays exposure will cause an apparent decrease in the pathogenic bacteria’s.Keywords
Bacteria, Effect, Eco friendly, Pathogenic and Ultraviolet, Innovative technology, Innovative technique.References
- Gascón J, Oubiña A, Pérez-Lezaun A, Urmeneta J. Sensitivity of selected bacterial species to UV radiation. Current microbiology. 1995 Mar;30(3):177-82.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1535-41.
- Jahani R, Mojab F, Mahboubi A, Nasiri A, Tahamtani A, Faizi M. An In-Vivo Study on Anticonvulsant, Anxiolytic, and SedativeHypnotic Effects of the Polyphenol-Rich Thymus Kotschyanus Extract; Evidence for the Involvement of GABAA Receptors. Iranian Journal of Pharmaceutical Research: IJPR. 2019;18(3):1456.
- Khatua S, Paul S, Acharya K. Mushroom as the potential source of new generation of antioxidant: a review. Research Journal of Pharmacy and Technology. 2013;6(5):496-505.
- Karthikeyan D, Bhowmick M, Pandey VP, Sengottuvelu S, Sonkar S, Gupta N, Mohod V, Shivakumar T. Design and evaluation of ofloxacin extended release ocular inserts for once a day therapy. Research Journal of Pharmacy and Technology. 2008;1(4):460-8.
- John SL, Williams GP, Brijithlal ND, Namitha LH, Krishnakumar S. Effect of UV-β radiation on the Growth, Pigment production and Macromolecular contents in Marine microalgae. Research Journal of Pharmacy and Technology. 2019;12(12):5888-92.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Chakraborty P, Kumar S, Dutta D, Gupta V. Role of antioxidants in common health diseases. Research Journal of Pharmacy and Technology. 2009;2(2):238-44.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A Review. Research Journal of Pharmacy and Technology. 2008;1(4):328-40.
- Saravanan R, Dhachinamoorthi D, Senthil Kumar K, Vinodkumar S, Nikhileshbabu M, Neeraj J. Effects of UV-B Enhanced Solar Radiation on Trigonella foenum-graecum. Research J. Pharm. and Tech. 2012 Mar 1;5(3):328-32.
- Khelker T, Haque N, Agrawal A. Ultraviolet Protection potential of Curcuma longa L. and Citrus sinensis (L.) Osbeck. Research Journal of Pharmacy and Technology. 2017;10(12):4282-4.
- Kadivar H, Stapleton AE. Ultraviolet radiation alters maize phyllosphere bacterial diversity. Microbial Ecology. 2003 May 1:353-61.
- Yang Y, Itahashi S, Yokobori SI, Yamagishi A. UV-resistant bacteria isolated from upper troposphere and lower stratosphere. Biological Sciences in Space. 2008;22(1):18-25.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Häder DP, Helbling EW, Williamson CE, Worrest RC. Effects of UV radiation on aquatic ecosystems and interactions with climate change. Photochemical & Photobiological Sciences. 2011;10(2):242-60.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Pausz C, Herndl GJ. Role of nitrogen versus phosphorus availability on the effect of UV radiation on bacterioplankton and their recovery from previous UV stress. Aquatic microbial ecology. 2002 Sep 3;29(1):89-95.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Development and Validation of Stability Indicating RP-HPLC Method for Estimation of Levamisole HCl in Bulk and Tablet Dosage Form
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 2 (2022), Pagination: 111-116Abstract
A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1% Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20-µl. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Levamisole was performed (10-60µg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively The range of 10-60µg /ml was selected for the linearity of a standard Levamisole. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study.Linearity studies for Levamisole was performed on (10-60µg/ml).Keywords
RP-HPLC, Levamisole, Methanol, Ortho Phosphoric Acid.References
- Panchale WA, Suroshe R, Rathod MS, Pandhare YL. Chromatographic analysis of famotidine, paracetamol and ibuprofen from tablet formulation. Research Journal of Pharmacy and Technology. 2019;12(1): 231-6.
- Raju NA, Begum S. Simultaneous RP-HPLC method for the estimation of the emtricitabine, tenofovir disoproxil fumerate and efavirenz in tablet dosage forms. Research Journal of Pharmacy and Technology. 2008; 1(4): 522-5.
- Kumar VK, Raju NA, Begum S, Rao JV, Satyanarayana T. The Estimation of Aprepitant in Capsules Dosage forms by RP-HPLC. Research Journal of Pharmacy and Technology. 2009; 2(2): 412-4.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
- Sujana K, Sankar DG, Abbulu K. Simultaneous Estimation of Donepezil and Memantine by Reverse Phase HPLC in Bulk and Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2012 Jul 28; 5(7): 958-61.
- Rao CM, Konda R, Rao RN, Ramanjeneeyulu S, Reddy PG. Estimation of Nevirapine Anhydrous Bulk Formulation by Using IR, RP-HPLC, GC Methods. Research Journal of Pharmacy and Technology. 2010; 3(4): 1088-92.
- Singh M, Kashkhedikar SG, Soni L, Garg A, Gandhi T, Patel A. Development of RP-HPLC method for estimation of carvedilol in tablet formulations. Research Journal of Pharmacy and Technology. 2008; 1(1): 18-21.
- Reddy YB, Babu C, Channabasavaraj KP, Sharada CH, Panditi VR. Validated RP-HPLC Method for the Quantitative Estimation of Tramadol in Bulk and Pharmaceutical Dosage Forms. Research Journal of Pharmacy and Technology. 2010; 3(3): 781-3.
- Pai NR, Sawant SS. Development and validation of RP-HPLC method for estimation of olmesartan medoxomil in tablet dosage form. Research Journal of Pharmacy and Technology. 2013; 6(11): 1178-83.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18; 14(3):1535-41.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1): 86-94.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8): 624-9.
- García JJ, Diez MJ, Sierra M, Terán MT. Determination of levamisole by HPLC in plasma samples in the presence of heparin and pentobarbital. Journal of Liquid Chromatography. 1990 Feb 1; 13(4):743-9.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2): 94-100.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3): 4942-51.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Sari P, Sun J, Razzak M, Tucker IG. HPLC assay of levamisole and abamectin in sheep plasma for application to pharmacokinetic studies. Journal of Liquid Chromatography and Related Technologies. 2006 Sep 1;29(15):2277-90..
- Sari P, Razzak M, Tucker IG. Rapid, simultaneous determination of levamisole and abamectin in liquid formulations using HPLC. Journal of Liquid Chromatography and Related Technologies. 2004 Jan 1;27(2):351-64.
- Kitzman D, Cheng KJ, Fleckenstein L. HPLC assay for albendazole and metabolites in human plasma for clinical pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis. 2002 Oct 15;30(3):801-13.
- Valois ME, Takayanagui OM, Bonato PS, Lanchote VL, Carvalho D. Determination of albendazole metabolites in plasma by HPLC. Journal of Analytical Toxicology. 1994 Mar 1;18(2):86-90.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Development and Characterization of Hydrogel Containing Finasteride
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 281 - 286Abstract
The major goal of this study was to create a controlled-release dosage form utilizing a cellulose-based hydrogel that was cross-linked with propylene glycol. Hydrogels were made by crosslinking the polymer Sodium Alginate + Na CMC with propylene glycol, a suitable crosslinking agent. There is no indication of interaction between the medication, polymers, and other excipients, according to an IR and DSC analysis. The hydrogel gave good swelling and controlled release properties due to the cross linking process. The effect of Calcium Chloride concentration on drug content and t75 percent CDR was found to be non-significant based on the findings. However, the influence of Calcium Chloride concentration on swelling index was substantial, indicating that as Calcium Chloride concentration rose, the swelling index of the hydrogel decreased. Again, the effect of response time on drug content and t75 of percent CDR was substantial, implying that as reaction time rose, drug content and t75 of percent CDR of hydrogel increased as well. However, the effect of response time on the swelling index was not statistically significant. Drug content, swelling index, and t75 of percent CDR of run BB1 are the best than compared with based on all responses. This run's drug content, swelling index, and t75 percent CDR are respectively 99.5 percent, 276.64 percent, and 3.5 hrs. So BB1 was used to test the improved formulation, which produced the best in vitro release of 94.24 percent in 6hrs. Different kinetic models were fitted to the in vitro data which showed the best model was higuchi with non-fickian mode of drug release and stability data showed that the formulations were stable during the time span of the study. From the study it was concluded that the prepared hydrogel can provide a sustained release effect with better bioavailability which will surely enhance its absorption throughout the body.
Keywords
Finasteride, Hydrogel, Factorial Design, Cross-linking, Controlled-Release Dosage FormReferences
- Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. Journal of advanced research. 2015 Mar 1;6(2):105-21.
- Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced drug delivery reviews. 2010 Jan 31;62(1):83-99.
- Ishihara M, Obara K, Nakamura S, Fujita M, Masuoka K, Kanatani Y, Takase B, Hattori H, Morimoto Y, Ishihara M, Maehara T. Chitosan hydrogel as a drug delivery carrier to control angiogenesis. Journal of Artificial Organs. 2006 Mar;9(1):8-16.
- Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-5.
- Obaid FN, Jaffat HS. Physiological and histological study of the effect of finasteride drug (Prostacare) on the fertility of albino male rats. Research Journal of Pharmacy and Technology. 2018;11(6):2323-5.
- Park SY, Kim KB, Ahn SH, Kim HH. The effects of SM-215 on androgeneticalopecia. Research Journal of Pharmacy and Technology. 2018;11(5):1745-51.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Nandhakumar L, Dharmamoorthy G, Chandrasekaran S. Hydrogels: A multifaceted contemporary approaches and advancements. Research Journal of Pharmacy and Technology. 2011;4(11):1658-62.
- Deepthi B, Varun D, Gopal PN, Rao CH, Sumalatha G. Super porous hydrogels–Supreme drug delivery. Research Journal of Pharmacy and Technology. 2011;4(8):1182-8.
- Saranya R, Elango K, Devi DN, Balaguru A. Formulation and Evaluation of Hydrogel for Stomach Specific Drug Delivery of Lamivudine. Research Journal of Pharmacy and Technology. 2013;6(7):740-5.
- Kundu T, Mukherjee K, Biswanath S. Hydrogel beads composed of sodium carboxymethyl xanthan and sodium carboxymethyl cellulose for controlled release of aceclofenac: effect of formulation variables. Research Journal of Pharmacy and Technology. 2012;5(1):103-13.
- Saleem MA, Kulkarni RV, Patil NG. Formulation and evaluation of chitosan based polyelectrolyte complex hydrogels for extended release of metoprolol tartrate. Research Journal of Pharmacy and Technology. 2011;4(12):1844-51.
- Sami AJ, Khalid M, Jamil T, Aftab S, Mangat SA, Shakoori AR, Iqbal S. Formulation of novel chitosan guargum based hydrogels for sustained drug release of paracetamol. International journal of biological macromolecules. 2018 Mar 1;108:324-32.
- Sharma PK, Asthana GS, Asthana A. Formulation development and evaluation of hydrogel based gastroretentive drug delivery system of antihypertensive drug. Int. J. Pharm. Clin. Res. 2016;8(10):1396-401.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1;55(3):S672-80.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co- Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Shoichet MS, Li RH, White ML, Winn SR. Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose. Biotechnology and bioengineering. 1996 May 20;50(4):374-81.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian journal of pharmaceutical education and research. 2021 Jan 1;55(1):86-94.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- Formulation and Evaluation of Yohimbine HCl Proliposomal Gels
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 302 - 306Abstract
The study was aimed to develop a proliposomal formulation for anti- inflammatory drug Yohimbine HCl. Proliposomes with various concentrations of mannitol, phospholipid and cholesterol were prepared using thin- film hydration technique (vacuum rotatory evaporator). The optimization of proliposomal formulation was achieved based on Average size, Entrapment efficiency and drug content. The proliposomal formulation was incorporated in the gel (carbopol) and characterized for their rheology and in vitro drug release studies. The results of formulations revealed that maximum entrapment efficiency was dependent on phospholipid and cholesterol concentration. Rheological studies revealed that the proliposome formulation containing 2% w/w carbopol is stable for topical drug delivery. The In-vitro studies revealed that proliposomal gel formulation exhibits increased skin permeation showing sustain release when compared to that of pure drug.
Keywords
Proliposomes, Yohimbine HCl, film hydration, anti-inflammatory and Rheological studiesReferences
- Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research. 2015 Mar 1;6(2):105-21.
- Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced Drug Delivery Reviews. 2010 Jan 31;62(1):83-99.
- Ishihara M, Obara K, Nakamura S, Fujita M, Masuoka K, Kanatani Y, Takase B, Hattori H, Morimoto Y, Ishihara M, Maehara T. Chitosan hydrogel as a drug delivery carrier to control angiogenesis. Journal of Artificial Organs. 2006 Mar;9(1):8-16.
- Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-5.
- Obaid FN, Jaffat HS. Physiological and histological study of the effect of finasteride drug (Prostacare) on the fertility of albino male rats. Research Journal of Pharmacy and Technology. 2018;11(6):2323-5.
- Park SY, Kim KB, Ahn SH, Kim HH. The effects of SM-215 on androgeneticalopecia. Research Journal of Pharmacy and Technology. 2018;11(5):1745-51.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Nandhakumar L, Dharmamoorthy G, Chandrasekaran S. Hydrogels: A multifaceted contemporary approaches and advancements. Research Journal of Pharmacy and Technology. 2011;4(11):1658-62.
- Deepthi B, Varun D, Gopal PN, Rao CH, Sumalatha G. Super porous hydrogels–Supreme drug delivery. Research Journal of Pharmacy and Technology. 2011;4(8):1182-8.
- Saranya R, Elango K, Devi DN, Balaguru A. Formulation and Evaluation of Hydrogel for Stomach Specific Drug Delivery of Lamivudine. Research Journal of Pharmacy and Technology. 2013;6(7):740-5.
- Kundu T, Mukherjee K, Biswanath S. Hydrogel beads composed of sodium carboxymethyl xanthan and sodium carboxymethyl cellulose for controlled release of aceclofenac: effect of formulation variables. Research Journal of Pharmacy and Technology. 2012;5(1):103-13.
- Saleem MA, Kulkarni RV, Patil NG. Formulation and evaluation of chitosan based polyelectrolyte complex hydrogels for extended release of metoprolol tartrate. Research Journal of Pharmacy and Technology. 2011;4(12):1844-51.
- Sami AJ, Khalid M, Jamil T, Aftab S, Mangat SA, Shakoori AR, Iqbal S. Formulation of novel chitosan guargum based hydrogels for sustained drug release of paracetamol. International journal of biological macromolecules. 2018 Mar 1;108:324-32.
- Sharma PK, Asthana GS, Asthana A. Formulation development and evaluation of hydrogel based gastroretentive drug delivery system of antihypertensive drug. Int. J. Pharm. Clin. Res. 2016;8(10):1396-401.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1;55(3):S672-80.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co- Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Shoichet MS, Li RH, White ML, Winn SR. Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose. Biotechnology and Bioengineering. 1996 May 20;50(4):374-81.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 2 (2022), Pagination: 139-144Abstract
The present study aimed to develop an immediate release of Zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug releasewere found to be more than 60% in 15 minutes. This present studies concluded that Zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameters, it was concluded that the FJ5 formulation was found to be optimized formulation.Keywords
Oral Jelly, Migraine, Zolmitriptan Hydrochloride, Chitosan Hydrochloride.References
- Aminoff, Roger P. Simon, David A. Greenberg, Michael J. Clinical neurology (7 ed.). New York, N.Y: Lange Medical Books/McGraw-Hill. (2009) pp. 85–88.
- Malviya VR, Pande SD, Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-629.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Raja Manali M, Dhiren P, Oral medicated jelly: a recent advancement in formulation, An International Journal of Pharmaceutical Sciences, 2016; 7(2):13-20.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-5.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Kumar L. An Overview on Preparation and Evaluation of Microparticulated Intra-Vaginal Gel. Research Journal of Pharmacy and Technology. 2009;2(1):48-51.
- Shah RR, Magdum CS, Wadkar KA, Naikwade NS. Fluconazole topical microemulsion: preparation and evaluation. Research Journal of Pharmacy and Technology. 2009;2(2):353-7.
- Shete AS, Mohite VL, Yadav AV. Preparation and Evaluation of Mucilage of Ocimum Basilicum as a Gelling Agent. Research Journal of Pharmacy and Technology. 2008;1(3):201-3.
- Yadav AV, Urade MN. Preparation and evaluation of chitosan containing mucoadhesive buccal films of venlafaxine hydrochloride. Research Journal of Pharmacy and Technology. 2010;3(4):1213-7.
- Begum SA, Sree VP, Anusha V, Veronica ZK, Sree PV, Prameela K, Nazeema MD, Padmalatha K. Formulation and evaluation of pediatric oral soft jellies of salbutamol sulphate. Research Journal of Pharmacy and Technology. 2018;11(11):4939-45.
- Charyulu RN, Devi PP, Jose J, Shetty AV. Formulation and evaluation of mucoadhesive oral gel containing miconazole nitrate for oral candidiasis. Research Journal of Pharmacy and Technology. 2013;6(11):1251-7.
- Kumar R, Jose J, Mahin MM, Raut R, Masurkar S, Swamy VB. Formulation and Evaluation of Gels from Gum of Cissus refescence. Research Journal of Pharmacy and Technology. 2012;5(3):415-23.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1535-41.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Singh S. Drug Stability Testing and Shelf-life Determination According to International Guidelines. Pharm. Technol. 1999; 23:68-88
- Singh S, Bakshi M. Development of stability-indicating assay methods-A critical review. J. Pharm. Biomed. Anal. 2002; 28:1011-1040.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Design and Characterization of Sustained Released Alginate Beads of Meclizine Hydrochloride
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Angola,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 3 (2022), Pagination: 199-205Abstract
The objective of present study was to prepare alginate beads of antihistamine meclizine hydrochloride for sustain release action. The alginate beads were prepared by employing sodium alginate as a polymer with sodium carboxymethyl cellulose and chitosan hydrochloride as release retardant. The method of preparation employed was ionotropic gelation. The prepared beads were seen having the drug release rate of 98.34% of A4 batch and 99.02% of B4 batch in the time period of 12hrs. The maximum percent drug content of 94.72±0.06% was found in A4 batch. From the results it can be seen that A4 batch was found to be optimum as it was having maximum drug content and maximum amount of drug release in the predicted time period of 12hrs. Themicrobeads of meclizine hydrochloride by using ionotropic gelation method were prepared successfully employing various polymers in different concentrations. The prepared microbeads can be a better alternative than various other sustained release dosages forms.Keywords
Meclizine hydrochloride, Ionotropic Gelation, Anti-Histamine, Microbeads, Antiemetics.References
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12): 5972-6.
- Menon TV, Sajeeth CI. Formulation and evaluation of sustained release sodium alginate microbeads of carvedilol. Research Journal of Pharmacy and Technology. 2013;6(4):392-7.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
- Sivakumar R, Narayanan N, Rajendran NN. Bioadhesive Microbeads of Ketoprofen for Controlled and Site Specific Delivery. Research Journal of Pharmacy and Technology. 2011; 4(3): 385-8.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3): 4942-51.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1): 4745-52.
- Masareddy RS, Rananaware SD, Patil BR. Preparation and Characterization of Rabeprazole Gastroretentive Drug Delivery System by Ionotropic Gelation Technique. Research Journal of Pharmacy and Technology. 2010; 3(2): 526-9.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Jaiswal M, Lanjhiyana SK. Fabrication and Evaluations of Dual Crosslinked Mesalamine containing Pectin-Chitosan gel micro beads for controlled and targeted colon delivery. Research Journal of Pharmacy and Technology. 2018;11(11):4797-804.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Roy H, Balaiah S, Kumar TV. Design and In-vitro Evaluation of Cefuroxime axetil floating Microbeads for Treatment of acute Bacterial caused Chronic Bronchitis. Research Journal of Pharmacy and Technology. 2018;11(6):2276-82.
- Chauhan SB, Singh V, Chauhan R. Enteric coated Microbeads as a Potential Delivery System for improved probiotic effect of Lactobacillus rhamnosus GG. Research Journal of Pharmacy and Technology. 2019;12(12):6049-56.
- Chengaiah B, Alagusundaram M, Ramkanth S, Chetty CM. Self emulsifying drug delivery system: a novel approach for drug delivery. Research Journal of Pharmacy and Technology. 2011;4(2):175-81.
- Gnanaprakash K, Shekhar KB, Chetty C. A review on floating drug delivery system of H2 receptors. Research Journal of Pharmacy and Technology. 2011;4(4):502-9.
- Putney SD, Burke PA. Improving protein therapeutics with sustained-release formulations. Nature Biotechnology. 1998 Feb;16(2):153-7.
- Leroux JC, Allémann E, De Jaeghere F, Doelker E, Gurny R. Biodegradable nanoparticles—from sustained release formulations to improved site specific drug delivery. Journal of Controlled Release. 1996 May 1;39(2-3):339-50.
- Takahara J, Takayama K, Nagai T. Multi-objective simultaneous optimization technique based on an artificial neural network in sustained release formulations. Journal of Controlled Release. 1997 Nov 10;49(1):11-20.
- Lee HJ, Riley G, Johnson O, Cleland JL, Kim N, Charnis M, Bailey L, Duenas E, Shahzamani A, Marian M, Jones AJ. In vivo characterization of sustained-release formulations of human growth hormone. Journal of Pharmacology and Experimental Therapeutics. 1997 Jun 1;281(3):1431-9.
- Ankit B, Rathore RP, Tanwar YS, Gupta S, Bhaduka G. Oral sustained release dosage form: an opportunity to prolong the release of drug. IJARPB. 2013 Jan 1;3(1):7-14.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
- Hilton AK, Deasy PB. In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate. International Journal of Pharmaceutics. 1992 Oct 10;86(1):79-88.
- An Updated Review on Novel Drug Delivery System
Authors
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara,, TR
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 3 (2022), Pagination: 211-216Abstract
Novel drug delivery systems are the method for delivering of the medications to patients in such a manner which increases concentration of medications inside various body parts. The drug delivery widely found over nanomedicines that plan for employing nano particles mediated drugs delivery for combating downfall for the conventional drug delivery. The nano particles that loaded along with drug and target for the specific part of body where it must solely diseased tissues, hence by avoiding interactions along with the healthy tissues. The aim of targeted drugs delivery system is for the prolonged, localizing, and targeting and has the protected drugs interactions along with diseased tissues. The conventional drugs delivery systems are absorption of drugs around the biological membrane, the targeted releases systems release the drugs in the form of dosage. The pharmaceuticals innovation such as newer drugs delivery system presents the health professional along with wider range of the arsenal for treating disease with better efficacy, precision and the safety. In the future, it is hopeful that along with the more researches endeavor that focused in the arena in the coming future, a larger portion of conventional dosages form be replaced by the betterment of the health care delivery that expected to change over. The pharmacovigilance will provide the cost-efficient health care that helped for extending the better health care for underprivileged.Keywords
Delivery, Drug, Newer, Novel, System, Tissues.References
- Kothawade PI, Zate SU, Gajbe JW, Rathi MN, Yewale CP, Baheti DR. Design and Evaluation of Sustained Release Matrix Tablet of Metformin Hydrochloride. Research Journal of Pharmacy and Technology. 2010; 3(2):522-5.
- Kumar A, Sharma AK, Dutt R. A Review of Gastro-retentive Drug Delivery Systems for Antidiabetics and its present status. Research Journal of Pharmacy and Technology. 2021; 14(1):538-46.
- Zam W Gastrointestinal disorders. Research Journ , Dawod R. Overview of the Probiotics’ role in al of Pharmacy and Technology. 2020 Nov 13; 13(11):5557-61.
- Alange VV, Kulkarni RV. Colon targeted drug delivery through functionally modified natural biopolymers. Research Journal of Pharmacy and Technology. 2017; 10(6):1853-7.
- Mahmood T, Shamim A, Ahsan F, Parveen S, Shariq M. Foeniculum vulgare, Solanum nigrum and Cichorium intybus: A Collectanea of Pharmacological and Clinical uses. Research Journal of Pharmacy and Technology. 2021 Jan 29; 14(1):555-61.
- Timothy CN, Samyuktha PS, Brundha MP. Dental pulp Stem Cells in Regenerative Medicine–A Literature Review. Research Journal of Pharmacy and Technology. 2019; 12(8):4052-6.
- Selvan SR, Ganapathy D. Efficacy of fifth generation cephalosporins against methicillin-resistant Staphylococcus aureus-A review. Research Journal of Pharmacy and Technology. 2016; 9(10):1815-8.
- Dixit N, Trivedi A, Ahirwar D. Synthesis of Citosan Nanocarrier Systems for Improving SSRI-Fluoxetine Efficacy in MDD. Research Journal of Pharmacy and Technology. 2020; 13(5):2387- 92.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019; 12(12):5972-6.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8):624-9.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2):94-100.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3):4942-51.
- Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia. 2010 Oct 1; 81(7):680-9.
- Malviya VR, Tawar Dispersible Strips of Teneligliptin Hydrobromide f MG. Preparation and Evaluation of Oral or Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1):4745-52.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo CoAgglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1; 14(3):1535-41.
- Makeshwar KB, Wasankar SR. Niosome: a novel drug delivery 20.
- Lee SS, Robinson MR. Novel drug delivery systems for retinal diseases. Ophthalmic Research. 2009; 41(3):124-35.
- Barar J, Javadzadeh AR, Omidi Y. Ocular novel drug delivery: impacts of membranes and barriers. Expert Opinion on Drug Delivery. 2008 May 1; 5(5):567-81.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1):86-94.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28; 15(1):5782-93.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31; 14(10):5345-50.
- Shabreen MR, Sangeetha S. Ethosomes: A novel drug delivery system and their therapeutic applications-A review. Research Journal of Pharmacy and Technology. 2020 Apr 30; 13(4):1970-8.
- Sanghi DK, Tiwle R. Herbal drugs an emerging tool for novel drug delivery systems. Asian Journal of Research in Chemistry. 2013 Sep 1; 6(9):962.
- Monika B, Amit R, Sanjib B, Alisha B, Mihir P, Dhanushram T. Transdermal drug delivery system with formulation and evaluation aspects: overview. Research Journal of Pharmacy and Technology. 2012 Sep 1; 5(9):1168.
- Jassal M, Nautiyal U, Kundlas J, Singh D. A review: Gastroretentive drug delivery system (grdds). Indian Journal of Pharmaceutical and Biological Research. 2015 Jan 1; 3(1):82.
- Sarma A, Das MK, Chakraborty T, Das S. Nanostructured lipid carriers (NLCs)-based intranasal Drug Delivery System of Tenofovir disoproxil fumerate (TDF) for brain targeting. Research Journal of Pharmacy and Technology. 2020 Nov 13; 13(11):5411- 24.
- Kumar S, Rahaman A, Tyagi LK, Chandra A. Floating drug delivery system: A novel approach for gastroretentive drug delivery. Research Journal of Pharmacy and Technology. 2011; 4(7):1026-32.
- Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3):S672-80.